Forget "Save the cheerleader, Save the world" (From Heroes, for all of you non-tv watchers) - how about "Buy a t-shirt, feed an orphan"?
The Moju project is a great website that allows you, for the price of one t-shirt, to feed a hot meal each day for a month to an orphaned child in Africa. I came across this site just in time for Christmas shopping - instead of spending $25 on a Starbucks gift card for your niece, brother, or great-grandpa, get them a t-shirt that will directly impact the life of a needy child.
As the Moju (which means "to impact" in Estonian) website points out, if we work together, we can help change the lives of the millions of kids that live in poverty in Africa and can prevent some of the 16,000 hunger-related deaths of children each day.
Check out Moju's site, get a t-shirt for that hard-to-buy-for relative, and make a difference!